Answering the mistery of memory: Difference between revisions

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==Latest News==
==Latest News==
*September 7, 2022: [http://glutamate.med.kyoto-u.ac.jp/e/index.php/File:Yasuda_Nat_Rev_Neurosci_2022.pdf A new review on CaMKII] is published in Nature Review in Neuroscience.
*September 7, 2022: [http://glutamate.med.kyoto-u.ac.jp/shared/images/e/ed/Yasuda_Nat_Rev_Neurosci_2022.pdf A new review on CaMKII] is published in Nature Review in Neuroscience.
*November 12, 2021: [http://glutamate.med.kyoto-u.ac.jp/e/index.php/file:Goto_Science_2021.pdf A work] by [[Akihiro Goto]] (assistant professor) was published in Science. For details, please check "[[Erasing memory with light -Understanding why sleep is necessary for good memory-]]".
*November 12, 2021: [http://glutamate.med.kyoto-u.ac.jp/e/index.php/file:Goto_Science_2021.pdf A work] by [[Akihiro Goto]] (assistant professor) was published in Science. For details, please check "[[Erasing memory with light -Understanding why sleep is necessary for good memory-]]".
*April 29, 2021: [http://glutamate.med.kyoto-u.ac.jp/e/index.php/file:Hosokawa_Liu_Nat_Neurosci_2021.pdf A work] by Tomohisa Hosokawa (former postdoc) and Pinwu Liu (former graduate student) was published in Nature Neuroscience. For details, please check "[[An oil-water relationship explains memory formation - A new protein segregation mechanism in the brain]]".
*April 29, 2021: [http://glutamate.med.kyoto-u.ac.jp/e/index.php/file:Hosokawa_Liu_Nat_Neurosci_2021.pdf A work] by Tomohisa Hosokawa (former postdoc) and Pinwu Liu (former graduate student) was published in Nature Neuroscience. For details, please check "[[An oil-water relationship explains memory formation - A new protein segregation mechanism in the brain]]".

Latest revision as of 21:17, 6 December 2023

In 1953, a young man, later became known as a patient HM, underwent an experimental surgery to bilaterally remove hippocampi as treatment of the intractable epilepsy. Fortunately, HM's epilepsy became controllable but now he had another problem. While he could still recall his old memories, he could not memorize anything new. From the studies on the symptoms HM exhibited, we now know that hippocampus is the site where a memory is initially formed but not stored for long-term. But we still do not know the detailed mechanism by which memory is encoded in hippocampus, transferred to the rest of the brain, and recalled. This is one of oldest and most profound questions left for mankind.

In our laboratory, we approach this question from multiple levels of studies from molecules to animal behavior:

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