Publications

Original Papers

For papers before 2010, please see here.

2023

• Ripoli, C., Dagliyan, O., Renna, P., Pastore, F., Paciello, F., Sollazzo, R., Rinaudo, M., Battistoni, M., Martini, S., Tramutola, A., Sattin, A., Barone, E., Saneyoshi, T., Fellin, T., Hayashi, Y., & Grassi, C. (2023).
  Engineering memory with an extrinsically disordered kinase. Science advances, 9(46), eadh1110. [PubMed:37967196] [PMC] [WorldCat] [DOI]

2022

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  Özden, C., Sloutsky, R., Mitsugi, T., Santos, N., Agnello, E., Gaubitz, C., Foster, J., Lapinskas, E., Esposito, E.A., Saneyoshi, T., Kelch, B.A., Garman, S.C., Hayashi, Y., & Stratton, M.M. (2022).
  CaMKII binds both substrates and activators at the active site. Cell reports, 40(2), 111064. [PubMed:35830796] [PMC] [WorldCat] [DOI] [Google Scholar]

2021

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  Goto, A., Bota, A., Miya, K., Wang, J., Tsukamoto, S., Jiang, X., Hirai, D., Murayama, M., Matsuda, T., McHugh, T.J., Nagai, T., & Hayashi, Y. (2021).
  Stepwise synaptic plasticity events drive the early phase of memory consolidation. Science (New York, N.Y.), 374(6569), 857-863. [PubMed:34762472] [WorldCat] [DOI] [Google Scholar]
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  Cid, E., Marquez-Galera, A., Valero, M., Gal, B., Medeiros, D.C., Navarron, C.M., Ballesteros-Esteban, L., Reig-Viader, R., Morales, A.V., Fernandez-Lamo, I., Gomez-Dominguez, D., Sato, M., Hayashi, Y., Bayés, À., Barco, A., Lopez-Atalaya, J.P., & de la Prida, L.M. (2021).
  Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis. Cell reports, 35(10), 109229. [PubMed:34107264] [WorldCat] [DOI] [Google Scholar]
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  Takamura, R., Mizuta, K., Sekine, Y., Islam, T., Saito, T., Sato, M., Ohkura, M., Nakai, J., Ohshima, T., Saido, T.C., & Hayashi, Y. (2021).
  Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(24), 5315-5329. [PubMed:33980545] [PMC] [WorldCat] [DOI] [Google Scholar]
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  Hosokawa, T., Liu, P.W., Cai, Q., Ferreira, J.S., Levet, F., Butler, C., Sibarita, J.B., Choquet, D., Groc, L., Hosy, E., Zhang, M., & Hayashi, Y. (2021).
  CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation. Nature neuroscience, 24(6), 777-785. [PubMed:33927400] [WorldCat] [DOI] [Google Scholar]
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  Kastian, R.F., Minegishi, T., Baba, K., Saneyoshi, T., Katsuno-Kambe, H., Saranpal, S., Hayashi, Y., & Inagaki, N. (2021).
  Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines. Cell reports, 35(7), 109130. [PubMed:34010643] [WorldCat] [DOI] [Google Scholar]
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  Mizuta, K., Nakai, J., Hayashi, Y., & Sato, M. (2021).
  Multiple coordinated cellular dynamics mediate CA1 map plasticity. Hippocampus, 31(3), 235-243. [PubMed:33452849] [PMC] [WorldCat] [DOI] [Google Scholar]

2020

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  Eriksen, M.S., Nikolaienko, O., Hallin, E.I., Grødem, S., Bustad, H.J., Flydal, M.I., Merski, I., Hosokawa, T., Lascu, D., Akerkar, S., Cuéllar, J., Chambers, J.J., O'Connell, R., Muruganandam, G., Loris, R., Touma, C., Kanhema, T., Hayashi, Y., Stratton, M.M., Valpuesta, J.M., Kursula, P., Martinez, A., & Bramham, C.R. (2021).
  Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. The FEBS journal, 288(9), 2930-2955. [PubMed:33175445] [WorldCat] [DOI] [Google Scholar]
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  Sato, M., Mizuta, K., Islam, T., Kawano, M., Sekine, Y., Takekawa, T., Gomez-Dominguez, D., Schmidt, A., Wolf, F., Kim, K., Yamakawa, H., Ohkura, M., Lee, M.G., Fukai, T., Nakai, J., & Hayashi, Y. (2020).
  Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus. Cell reports, 32(1), 107864. [PubMed:32640229] [PMC] [WorldCat] [DOI] [Google Scholar]
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  Luchetti, A., Bota, A., Weitemier, A., Mizuta, K., Sato, M., Islam, T., McHugh, T.J., Tashiro, A., & Hayashi, Y. (2020).
  Two Functionally Distinct Serotonergic Projections into Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(25), 4936-4944. [PubMed:32414785] [PMC] [WorldCat] [DOI] [Google Scholar]
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  Cai, Q., Hosokawa, T., Zeng, M., Hayashi, Y., & Zhang, M. (2020).
  Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms. Structure (London, England : 1993), 28(3), 290-300.e4. [PubMed:31879129] [WorldCat] [DOI] [Google Scholar]

2019

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  Kojima, H., Rosendale, M., Sugiyama, Y., Hayashi, M., Horiguchi, Y., Yoshihara, T., Ikegaya, Y., Saneyoshi, T., & Hayashi, Y. (2019).
  The role of CaMKII-Tiam1 complex on learning and memory. Neurobiology of learning and memory, 166, 107070. [PubMed:31445077] [WorldCat] [DOI] [Google Scholar]
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  Saneyoshi, T., Matsuno, H., Suzuki, A., Murakoshi, H., Hedrick, N.G., Agnello, E., O'Connell, R., Stratton, M.M., Yasuda, R., & Hayashi, Y. (2019).
  Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP. Neuron, 102(6), 1199-1210.e6. [PubMed:31078368] [PMC] [WorldCat] [DOI] [Google Scholar]
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  Ghandour, K., Ohkawa, N., Fung, C.C.A., Asai, H., Saitoh, Y., Takekawa, T., Okubo-Suzuki, R., Soya, S., Nishizono, H., Matsuo, M., Osanai, M., Sato, M., Ohkura, M., Nakai, J., Hayashi, Y., Sakurai, T., Kitamura, T., Fukai, T., & Inokuchi, K. (2019).
  Orchestrated ensemble activities constitute a hippocampal memory engram. Nature communications, 10(1), 2637. [PubMed:31201332] [PMC] [WorldCat] [DOI] [Google Scholar]
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  Kobayashi, T., Islam, T., Sato, M., Ohkura, M., Nakai, J., Hayashi, Y., & Okamoto, H. (2019).
  Wide and Deep Imaging of Neuronal Activities by a Wearable NeuroImager Reveals Premotor Activity in the Whole Motor Cortex. Scientific reports, 9(1), 8366. [PubMed:31182818] [PMC] [WorldCat] [DOI] [Google Scholar]
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  Kim, K., Suzuki, A., Kojima, H., Kawamura, M., Miya, K., Abe, M., Yamada, I., Furuse, T., Wakana, S., Sakimura, K., & Hayashi, Y. (2019).
  Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning. Neurobiology of learning and memory, 157, 86-95. [PubMed:30528771] [WorldCat] [DOI] [Google Scholar]

2018

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  Hallin, E.I., Eriksen, M.S., Baryshnikov, S., Nikolaienko, O., Grødem, S., Hosokawa, T., Hayashi, Y., Bramham, C.R., & Kursula, P. (2018).
  Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. Journal of neurochemistry, 147(3), 323-343. [PubMed:30028513] [WorldCat] [DOI] [Google Scholar]
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  Kashino, Y., Obara, Y., Okamoto, Y., Saneyoshi, T., Hayashi, Y., & Ishii, K. (2018).
  ERK5 Phosphorylates K_v4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells. International journal of molecular sciences, 19(7). [PubMed:29996472] [PMC] [WorldCat] [DOI] Google Scholar

2017

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  Sato, M., Kawano, M., Mizuta, K., Islam, T., Lee, M.G., & Hayashi, Y. (2017).
  Hippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality. eNeuro, 4(3). [PubMed:28484738] [PMC] [WorldCat] [DOI] [Google Scholar]
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  Bosch, M., Castro, J., Sur, M., & Hayashi, Y. (2017).
  Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microcopy Imaging of Single Stimulated Synapses. Methods in molecular biology (Clifton, N.J.), 1538, 185-214. [PubMed:27943192] [WorldCat] [DOI] [Google Scholar]

2016

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  Sato, M., Kawano, M., Yanagawa, Y., & Hayashi, Y. (2016).
  In vivo two-photon imaging of striatal neuronal circuits in mice. Neurobiology of learning and memory, 135, 146-151. [PubMed:27400866] [WorldCat] [DOI] [Google Scholar]

2015

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  Kim, K., Lakhanpal, G., Lu, H.E., Khan, M., Suzuki, A., Hayashi, M.K., Narayanan, R., Luyben, T.T., Matsuda, T., Nagai, T., Blanpied, T.A., Hayashi, Y., & Okamoto, K. (2015).
  A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII. Neuron, 87(4), 813-26. [PubMed:26291163] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Hosokawa, T., Mitsushima, D., Kaneko, R., & Hayashi, Y. (2015).
  Stoichiometry and phosphoisotypes of hippocampal AMPA-type glutamate receptor phosphorylation. Neuron, 85(1), 60-67. [PubMed:25533481] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Sato, M., Kawano, M., Ohkura, M., Gengyo-Ando, K., Nakai, J., & Hayashi, Y. (2015).
  Generation and Imaging of Transgenic Mice that Express G-CaMP7 under a Tetracycline Response Element. PloS one, 10(5), e0125354. [PubMed:25946002] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Sakaguchi, M., Kim, K., Yu, L.M., Hashikawa, Y., Sekine, Y., Okumura, Y., Kawano, M., Hayashi, M., Kumar, D., Boyden, E.S., McHugh, T.J., & Hayashi, Y. (2015).
  Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice. PloS one, 10(6), e0130163. [PubMed:26075894] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Matsuno, H., Ohi, K., Hashimoto, R., Yamamori, H., Yasuda, Y., Fujimoto, M., Yano-Umeda, S., Saneyoshi, T., Takeda, M., & Hayashi, Y. (2015).
  A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia. PloS one, 10(3), e0116319. [PubMed:25768306] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Manita, S., Suzuki, T., Homma, C., Matsumoto, T., Odagawa, M., Yamada, K., Ota, K., Matsubara, C., Inutsuka, A., Sato, M., Ohkura, M., Yamanaka, A., Yanagawa, Y., Nakai, J., Hayashi, Y., Larkum, M.E., & Murayama, M. (2015).
  A Top-Down Cortical Circuit for Accurate Sensory Perception. Neuron, 86(5), 1304-16. [PubMed:26004915] [WorldCat] [DOI] [Google Scholar]

2014

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  Bosch, M., Castro, J., Saneyoshi, T., Matsuno, H., Sur, M., & Hayashi, Y. (2014).
  Structural and molecular remodeling of dendritic spine substructures during long-term potentiation. Neuron, 82(2), 444-59. [PubMed:24742465] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Martinez-Lozada, Z., Waggener, C.T., Kim, K., Zou, S., Knapp, P.E., Hayashi, Y., Ortega, A., & Fuss, B. (2014).
  Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain. Glia, 62(9), 1543-1558. [PubMed:24866099] [PMC] [WorldCat] [DOI] [Google Scholar]

2013

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  Ueda, Y., & Hayashi, Y. (2013).
  PIP₃ regulates spinule formation in dendritic spines during structural long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(27), 11040-7. [PubMed:23825409] [PMC] [WorldCat] [DOI] [Google Scholar]

2012

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  Wang, D.O., Matsuno, H., Ikeda, S., Nakamura, A., Yanagisawa, H., Hayashi, Y., & Okamoto, A. (2012).
  A quick and simple FISH protocol with hybridization-sensitive fluorescent linear oligodeoxynucleotide probes. RNA (New York, N.Y.), 18(1), 166-75. [PubMed:22101241] [PMC] [WorldCat] [DOI] [Google Scholar]

2011

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  Mower, A.F., Kwok, S., Yu, H., Majewska, A.K., Okamoto, K., Hayashi, Y., & Sur, M. (2011).
  Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo. Proceedings of the National Academy of Sciences of the United States of America, 108(52), 21241-6. [PubMed:22160721] [PMC] [WorldCat] [DOI] [Google Scholar]

Preprints

2022

• Takashi Takekawa, Masanori Nomoto, Hirotaka Asai, Noriaki Ohkawa, Reiko Okubo-Suzuki, Khaled Ghandour, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Shin-ichi Muramatsu, Yasunori Hayashi, Kaoru Inokuchi, Tomoki Fukai
  HOTARU: Automatic sorting system for large scale calcium imaging data
  bioRxiv [DOI]

2021

• Ayaka Bota, Akihiro Goto, Suzune Tsukamoto, Alexander Schmidt, Fred Wolf, Alessandro Luchetti, Junichi Nakai, Hajime Hirase, Yasunori Hayashi
  Shared and unique properties of place cells in anterior cingulate cortex and hippocampus
  bioRxiv 2021.03.29.437441 [DOI][Google Scholar]
• Elena Cid, Angel Marquez-Galera, Manuel Valero, Beatriz Gal, Daniel C. Medeiros, Carmen M. Navarrón, Luis Ballesteros-Esteban, Rita Reig-Viader, Aixa V. Morales, Ivan Fernandez-Lamo, Daniel Gomez-Dominguez, Masaaki Sato, Yasunori Hayashi, Àlex Bayés, Angel Barco, Jose P López-Atalaya, Liset M de la Prida
  Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis
  bioRxiv 2021.02.03.429560; [DOI]

2020

• Tomohisa Hosokawa, Pin-Wu Liu, Qixu Cai, Joana S Ferreira, Florian Levet, Corey Butler, Jean-Baptiste Sibarita, Daniel Choquet, Laurent Groc, Eric Hosy, Mingjie Zhang, Yasunori Hayashi
  CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase
  bioRxiv 2020.11.25.397091; DOI
• Can Özden, Roman Sloutsky, Nicholas Santos, Emily Agnello, Christl Gaubitz, Emily Lapinskas, Edward A. Esposito, Brian A. Kelch, Scott C. Garman, Yasunori Hayashi, Margaret M. Stratton
  CaMKII binds both substrates and effectors at the active site
  bioRxiv 2020.10.25.354241; DOI

2019

• Maria Steene Eriksen, Oleksii Nikolaienko, Erik Ingmar Hallin, Sverre Grødem, Helene J. Bustad, Marte Innselset Flydal, Rory O’Connell, Tomohisa Hosokawa, Daniela Lascu, Shreeram Akerkar, Jorge Cuéllar, James J. Chambers, Ian Merski, Gopinath Muruganandam, Remy Loris, Tambudzai Kanhema, Yasunori Hayashi, Margaret M. Stratton, José M. Valpuesta, Petri Kursula, Aurora Martinez, Clive R. Bramham
  Molecular determinants of Arc oligomerization and formation of virus-like capsids
  bioRxiv 667956; DOI

2018

• Takuma Kobayashi, Tanvir Islam, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Yasunori Hayashi, Hitoshi Okamoto
  Wide and Deep Imaging of Neuronal Activities by a Wearable NeuroImager Reveals Premotor Activity in the Whole Motor Cortex
  bioRxiv 434035; DOI
• Erik I. Hallin, Maria S. Eriksen, Sergei Baryshnikov, Oleksii Nikolaienko, Sverre Grødem, Tomohisa Hosokawa, Yasunori Hayashi, Clive R. Bramham, Petri Kursula
  Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities
  bioRxiv 332015; DOI
• Masaaki Sato, Kotaro Mizuta, Tanvir Islam, Masako Kawano, Takashi Takekawa, Daniel Gomez-Dominguez, Karam Kim, Hiroshi Yamakawa, Masamichi Ohkura, Tomoki Fukai, Junichi Nakai, Yasunori Hayashi
  Dynamic embedding of salience coding in hippocampal spatial maps
  bioRxiv 266767; DOI

2017

• Takashi Takekawa, Hirotaka Asai, Noriaki Ohkawa, Masanori Nomoto, Reiko Okubo-Suzuki, Khaled Ghandour, Masaaki Sato, Yasunori Hayashi, Kaoru Inokuchi, Tomoki Fukai
  Automatic sorting system for large calcium imaging data
  bioRxiv 215145; DOI

Reviews and Commentaries

For reviews and commentaries before 2010, please see here.

2023

• 
  Goto, A., & Hayashi, Y. (2023).
  Offline neuronal activity and synaptic plasticity during sleep and memory consolidation. Neuroscience research, 189, 29-36. [PubMed:36584924] [WorldCat] [DOI] [Google Scholar]

2022

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  Yasuda, R., Hayashi, Y., & Hell, J.W. (2022).
  CaMKII: a central molecular organizer of synaptic plasticity, learning and memory. Nature reviews. Neuroscience, 23(11), 666-682. [PubMed:36056211] [WorldCat] [DOI] [Google Scholar]

2021

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  Hayashi, Y. (2022).
  Molecular mechanism of hippocampal long-term potentiation - Towards multiscale understanding of learning and memory. Neuroscience research, 175, 3-15. [PubMed:34375719] [WorldCat] [DOI] [Google Scholar]

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  Liu, P.W., Hosokawa, T., & Hayashi, Y. (2021).
  Regulation of synaptic nanodomain by liquid-liquid phase separation: A novel mechanism of synaptic plasticity. Current opinion in neurobiology, 69, 84-92. [PubMed:33752045] [WorldCat] [DOI] [Google Scholar]

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  Hayashi, Y., Ford, L.K., Fioriti, L., McGurk, L., & Zhang, M. (2021).
  Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(5), 834-844. [PubMed:33472825] [PMC] [WorldCat] [DOI] [Google Scholar]

2019

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  Hayashi, Y. (2019).
  Drebrin-Homer Interaction at An Atomic Scale. Structure (London, England : 1993), 27(1), 3-5. [PubMed:30605660] [WorldCat] [DOI] [Google Scholar]

2017

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  Lissek, T., Adams, M., Adelman, J., Ahissar, E., Akaaboune, M., Akil, H., al'Absi, M., Arain, F., Arango-Lasprilla, J.C., Atasoy, D., Avila, J., Badawi, A., Bading, H., Baig, A.M., Baleriola, J., Belmonte, C., Bertocchi, I., Betz, H., Blakemore, C., Blanke, O., Boehm-Sturm, P., Bonhoeffer, T., Bonifazi, P., Brose, N., Campolongo, P., Celikel, T., Chang, C.C., Chang, T.Y., Citri, A., ..., & Hasan, M.T. (2017).
  Building Bridges through Science. Neuron, 96(4), 730-735. [PubMed:29144972] [WorldCat] [DOI] [Google Scholar]

2016

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  Kim, K., Saneyoshi, T., Hosokawa, T., Okamoto, K., & Hayashi, Y. (2016).
  Interplay of enzymatic and structural functions of CaMKII in long-term potentiation. Journal of neurochemistry, 139(6), 959-972. [PubMed:27207106] [WorldCat] [DOI] [Google Scholar]

2014

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  Saneyoshi, T., & Hayashi, Y. (2014).
  Synapse reorganization-a new partnership revealed. The EMBO journal, 33(12), 1292-4. [PubMed:24764316] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Kim, K., & Hayashi, Y. (2014).
  CaMKII: the Swiss army knife of synaptic plasticity. The Journal of physiology, 592(22), 4807-8. [PubMed:25399030] [PMC] [WorldCat] [DOI] [Google Scholar]

2013

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  Ueda, Y., Kwok, S., & Hayashi, Y. (2013).
  Application of FRET probes in the analysis of neuronal plasticity. Frontiers in neural circuits, 7, 163. [PubMed:24133415] [PMC] [WorldCat] [DOI] [Google Scholar]

2012

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  Saneyoshi, T., & Hayashi, Y. (2012).
  The Ca2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines. Cytoskeleton (Hoboken, N.J.), 69(8), 545-54. [PubMed:22566410] [WorldCat] [DOI] [Google Scholar]

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  Sakaguchi, M., & Hayashi, Y. (2012).
  Catching the engram: strategies to examine the memory trace. Molecular brain, 5, 32. [PubMed:22999350] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Hayashi, Y., Okamoto, K., Bosch, M., & Futai, K. (2012).
  Roles of neuronal activity-induced gene products in Hebbian and homeostatic synaptic plasticity, tagging, and capture. Advances in experimental medicine and biology, 970, 335-54. [PubMed:22351063] [WorldCat] [DOI] [Google Scholar]

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  Bosch, M., & Hayashi, Y. (2012).
  Structural plasticity of dendritic spines. Current opinion in neurobiology, 22(3), 383-8. [PubMed:21963169] [PMC] [WorldCat] [DOI] [Google Scholar]

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