Answering the mistery of memory: Difference between revisions
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[[j:記憶の謎を解き明かす]] | [[j:記憶の謎を解き明かす]] | ||
[[file:Cajal Hippocampus.jpg|thumbnail|Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).]] | |||
[[file:Thy1-hippocampus-merge.png|thumbnail|Mouse hippocampal section from a transgenic line expressing G-CaMP7 and DsRed2.]] | |||
In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories. | In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories. | ||
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* [[Projects#Molecular_Mechanisms_of_Structural_Plasticity_of_Dendritic_Spines|Molecular Mechanisms of Structural Plasticity of Dendritic Spines]] | * [[Projects#Molecular_Mechanisms_of_Structural_Plasticity_of_Dendritic_Spines|Molecular Mechanisms of Structural Plasticity of Dendritic Spines]] | ||
* [[Projects#Dynamic_Behavior_of_Cellular_Memory_Engram|Dynamic Behavior of Cellular Memory Engram]] | * [[Projects#Dynamic_Behavior_of_Cellular_Memory_Engram|Dynamic Behavior of Cellular Memory Engram]] | ||
== Latest News == | == Latest News == | ||
Latest revision as of 13:08, 13 April 2026
In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.
Subsequent studies of H.M. demonstrated that the hippocampus is indispensable for the initial encoding of memory, yet is not the ultimate site of long-term storage. However, the mechanisms by which memories are encoded within the hippocampus, reorganized across distributed brain networks, and subsequently retrieved remain incompletely understood. Elucidating these processes constitutes a central objective in contemporary neuroscience.
Our laboratory addresses this problem through an integrative, multi-scale approach spanning molecular, cellular, circuit, and behavioral levels:
- Protein trafficking in long-term potentiation
- Liquid-liquid phase separation and synaptic plasticity
- Molecular Mechanisms of Structural Plasticity of Dendritic Spines
- Dynamic Behavior of Cellular Memory Engram
Latest News
- November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”
- April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”