Answering the mistery of memory: Difference between revisions
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Our laboratory addresses this problem through an integrative, multi-scale approach spanning molecular, cellular, circuit, and behavioral levels: | Our laboratory addresses this problem through an integrative, multi-scale approach spanning molecular, cellular, circuit, and behavioral levels: | ||
Protein trafficking in long-term potentiation | * [[Projects#Protein_Trafficking_and_Long-term_Potentiation|Protein trafficking in long-term potentiation]] | ||
* [[Projects#Liquid-liquid_phase_separation_and_synaptic_plasticity|Liquid-liquid phase separation and synaptic plasticity]] | |||
Molecular | * [[Projects#Molecular_Mechanisms_of_Structural_Plasticity_of_Dendritic_Spines|Molecular Mechanisms of Structural Plasticity of Dendritic Spines]] | ||
Dynamic | * [[Projects#Dynamic_Behavior_of_Cellular_Memory_Engram|Dynamic Behavior of Cellular Memory Engram]] | ||
Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining). | Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining). | ||
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== Latest News == | == Latest News == | ||
November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”<br> | * November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”<br> | ||
April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.” | * April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.” | ||
Revision as of 12:33, 13 April 2026
In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.
Subsequent studies of H.M. demonstrated that the hippocampus is indispensable for the initial encoding of memory, yet is not the ultimate site of long-term storage. However, the mechanisms by which memories are encoded within the hippocampus, reorganized across distributed brain networks, and subsequently retrieved remain incompletely understood. Elucidating these processes constitutes a central objective in contemporary neuroscience.
Our laboratory addresses this problem through an integrative, multi-scale approach spanning molecular, cellular, circuit, and behavioral levels:
- Protein trafficking in long-term potentiation
- Liquid-liquid phase separation and synaptic plasticity
- Molecular Mechanisms of Structural Plasticity of Dendritic Spines
- Dynamic Behavior of Cellular Memory Engram
Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).
Mouse hippocampal section from a transgenic line expressing G-CaMP7 and DsRed2.
Latest News
- November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”
- April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”