Publications

Original Publications

2025

• File:Liu Neurosci Res 2025.pdfLiu, J., Goto, A. & Hayashi, Y. (in press)
  Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall. Neurosci. Res.

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  Pandey,V., Hosokawa, T. Hayashi, Y. & Urakubo, H. (in press)
  Multiphasic protein condensation governed by shape and valency. Cell Reports

2024

• Kaizuka, T., Hirouchi, T., Saneyoshi, T., Shirafuji, T., Collins, M.O., Grant, S.G.N., Hayashi, Y., & Takumi, T. (2024).
  FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. PLoS biology, 22(3), e3002006. [PubMed:38452102] [PMC] [WorldCat] [DOI]

2023

• Ripoli, C., Dagliyan, O., Renna, P., Pastore, F., Paciello, F., Sollazzo, R., Rinaudo, M., Battistoni, M., Martini, S., Tramutola, A., Sattin, A., Barone, E., Saneyoshi, T., Fellin, T., Hayashi, Y., & Grassi, C. (2023).
  Engineering memory with an extrinsically disordered kinase. Science advances, 9(46), eadh1110. [PubMed:37967196] [PMC] [WorldCat] [DOI] [Google Scholar]

2022

• Özden, C., Sloutsky, R., Mitsugi, T., Santos, N., Agnello, E., Gaubitz, C., Foster, J., Lapinskas, E., Esposito, E.A., Saneyoshi, T., Kelch, B.A., Garman, S.C., Hayashi, Y., & Stratton, M.M. (2022).
  CaMKII binds both substrates and activators at the active site. Cell reports, 40(2), 111064. [PubMed:35830796] [PMC] [WorldCat] [DOI] [Google Scholar]

2021

• Goto, A., Bota, A., Miya, K., Wang, J., Tsukamoto, S., Jiang, X., Hirai, D., Murayama, M., Matsuda, T., McHugh, T.J., Nagai, T., & Hayashi, Y. (2021).
  Stepwise synaptic plasticity events drive the early phase of memory consolidation. Science (New York, N.Y.), 374(6569), 857-863. [PubMed:34762472] [WorldCat] [DOI] [Google Scholar]
• Cid, E., Marquez-Galera, A., Valero, M., Gal, B., Medeiros, D.C., Navarron, C.M., Ballesteros-Esteban, L., Reig-Viader, R., Morales, A.V., Fernandez-Lamo, I., Gomez-Dominguez, D., Sato, M., Hayashi, Y., Bayés, À., Barco, A., Lopez-Atalaya, J.P., & de la Prida, L.M. (2021).
  Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis. Cell reports, 35(10), 109229. [PubMed:34107264] [WorldCat] [DOI] [Google Scholar]
• Takamura, R., Mizuta, K., Sekine, Y., Islam, T., Saito, T., Sato, M., Ohkura, M., Nakai, J., Ohshima, T., Saido, T.C., & Hayashi, Y. (2021).
  Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(24), 5315-5329. [PubMed:33980545] [PMC] [WorldCat] [DOI] [Google Scholar]
• Hosokawa, T., Liu, P.W., Cai, Q., Ferreira, J.S., Levet, F., Butler, C., Sibarita, J.B., Choquet, D., Groc, L., Hosy, E., Zhang, M., & Hayashi, Y. (2021).
  CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation. Nature neuroscience, 24(6), 777-785. [PubMed:33927400] [WorldCat] [DOI] [Google Scholar]
• Kastian, R.F., Minegishi, T., Baba, K., Saneyoshi, T., Katsuno-Kambe, H., Saranpal, S., Hayashi, Y., & Inagaki, N. (2021).
  Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines. Cell reports, 35(7), 109130. [PubMed:34010643] [WorldCat] [DOI] [Google Scholar]
• Mizuta, K., Nakai, J., Hayashi, Y., & Sato, M. (2021).
  Multiple coordinated cellular dynamics mediate CA1 map plasticity. Hippocampus, 31(3), 235-243. [PubMed:33452849] [PMC] [WorldCat] [DOI] [Google Scholar]

2020

• Eriksen, M.S., Nikolaienko, O., Hallin, E.I., Grødem, S., Bustad, H.J., Flydal, M.I., Merski, I., Hosokawa, T., Lascu, D., Akerkar, S., Cuéllar, J., Chambers, J.J., O'Connell, R., Muruganandam, G., Loris, R., Touma, C., Kanhema, T., Hayashi, Y., Stratton, M.M., Valpuesta, J.M., Kursula, P., Martinez, A., & Bramham, C.R. (2021).
  Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. The FEBS journal, 288(9), 2930-2955. [PubMed:33175445] [WorldCat] [DOI] [Google Scholar]
• Sato, M., Mizuta, K., Islam, T., Kawano, M., Sekine, Y., Takekawa, T., Gomez-Dominguez, D., Schmidt, A., Wolf, F., Kim, K., Yamakawa, H., Ohkura, M., Lee, M.G., Fukai, T., Nakai, J., & Hayashi, Y. (2020).
  Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus. Cell reports, 32(1), 107864. [PubMed:32640229] [PMC] [WorldCat] [DOI] [Google Scholar]
• Luchetti, A., Bota, A., Weitemier, A., Mizuta, K., Sato, M., Islam, T., McHugh, T.J., Tashiro, A., & Hayashi, Y. (2020).
  Two Functionally Distinct Serotonergic Projections into Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(25), 4936-4944. [PubMed:32414785] [PMC] [WorldCat] [DOI] [Google Scholar]
• Cai, Q., Hosokawa, T., Zeng, M., Hayashi, Y., & Zhang, M. (2020).
  Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms. Structure (London, England : 1993), 28(3), 290-300.e4. [PubMed:31879129] [WorldCat] [DOI] [Google Scholar]

2019

• Kojima, H., Rosendale, M., Sugiyama, Y., Hayashi, M., Horiguchi, Y., Yoshihara, T., Ikegaya, Y., Saneyoshi, T., & Hayashi, Y. (2019).
  The role of CaMKII-Tiam1 complex on learning and memory. Neurobiology of learning and memory, 166, 107070. [PubMed:31445077] [WorldCat] [DOI] [Google Scholar]
• Saneyoshi, T., Matsuno, H., Suzuki, A., Murakoshi, H., Hedrick, N.G., Agnello, E., O'Connell, R., Stratton, M.M., Yasuda, R., & Hayashi, Y. (2019).
  Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP. Neuron, 102(6), 1199-1210.e6. [PubMed:31078368] [PMC] [WorldCat] [DOI] [Google Scholar]
• Ghandour, K., Ohkawa, N., Fung, C.C.A., Asai, H., Saitoh, Y., Takekawa, T., Okubo-Suzuki, R., Soya, S., Nishizono, H., Matsuo, M., Osanai, M., Sato, M., Ohkura, M., Nakai, J., Hayashi, Y., Sakurai, T., Kitamura, T., Fukai, T., & Inokuchi, K. (2019).
  Orchestrated ensemble activities constitute a hippocampal memory engram. Nature communications, 10(1), 2637. [PubMed:31201332] [PMC] [WorldCat] [DOI] [Google Scholar]
• Kobayashi, T., Islam, T., Sato, M., Ohkura, M., Nakai, J., Hayashi, Y., & Okamoto, H. (2019).
  Wide and Deep Imaging of Neuronal Activities by a Wearable NeuroImager Reveals Premotor Activity in the Whole Motor Cortex. Scientific reports, 9(1), 8366. [PubMed:31182818] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Kim, K., Suzuki, A., Kojima, H., Kawamura, M., Miya, K., Abe, M., Yamada, I., Furuse, T., Wakana, S., Sakimura, K., & Hayashi, Y. (2019).
  Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning. Neurobiology of learning and memory, 157, 86-95. [PubMed:30528771] [WorldCat] [DOI]

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2018

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  Hallin, E.I., Eriksen, M.S., Baryshnikov, S., Nikolaienko, O., Grødem, S., Hosokawa, T., Hayashi, Y., Bramham, C.R., & Kursula, P. (2018).
  Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. Journal of neurochemistry, 147(3), 323-343. [PubMed:30028513] [WorldCat] [DOI]

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  Kashino, Y., Obara, Y., Okamoto, Y., Saneyoshi, T., Hayashi, Y., & Ishii, K. (2018).
  ERK5 Phosphorylates K_v4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells. International journal of molecular sciences, 19(7). [PubMed:29996472] [PMC] [WorldCat] [DOI]

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2017

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  Sato, M., Kawano, M., Mizuta, K., Islam, T., Lee, M.G., & Hayashi, Y. (2017).
  Hippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality. eNeuro, 4(3). [PubMed:28484738] [PMC] [WorldCat] [DOI]

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  Bosch, M., Castro, J., Sur, M., & Hayashi, Y. (2017).
  Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microcopy Imaging of Single Stimulated Synapses. Methods in molecular biology (Clifton, N.J.), 1538, 185-214. [PubMed:27943192] [WorldCat] [DOI]

  [Google Scholar]

2016

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  Sato, M., Kawano, M., Yanagawa, Y., & Hayashi, Y. (2016).
  In vivo two-photon imaging of striatal neuronal circuits in mice. Neurobiology of learning and memory, 135, 146-151. [PubMed:27400866] [WorldCat] [DOI] [Google Scholar]

2015

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  Kim, K., Lakhanpal, G., Lu, H.E., Khan, M., Suzuki, A., Hayashi, M.K., Narayanan, R., Luyben, T.T., Matsuda, T., Nagai, T., Blanpied, T.A., Hayashi, Y., & Okamoto, K. (2015).
  A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII. Neuron, 87(4), 813-26. [PubMed:26291163] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Hosokawa, T., Mitsushima, D., Kaneko, R., & Hayashi, Y. (2015).
  Stoichiometry and phosphoisotypes of hippocampal AMPA-type glutamate receptor phosphorylation. Neuron, 85(1), 60-67. [PubMed:25533481] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Sato, M., Kawano, M., Ohkura, M., Gengyo-Ando, K., Nakai, J., & Hayashi, Y. (2015).
  Generation and Imaging of Transgenic Mice that Express G-CaMP7 under a Tetracycline Response Element. PloS one, 10(5), e0125354. [PubMed:25946002] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Sakaguchi, M., Kim, K., Yu, L.M., Hashikawa, Y., Sekine, Y., Okumura, Y., Kawano, M., Hayashi, M., Kumar, D., Boyden, E.S., McHugh, T.J., & Hayashi, Y. (2015).
  Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice. PloS one, 10(6), e0130163. [PubMed:26075894] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Matsuno, H., Ohi, K., Hashimoto, R., Yamamori, H., Yasuda, Y., Fujimoto, M., Yano-Umeda, S., Saneyoshi, T., Takeda, M., & Hayashi, Y. (2015).
  A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia. PloS one, 10(3), e0116319. [PubMed:25768306] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Manita, S., Suzuki, T., Homma, C., Matsumoto, T., Odagawa, M., Yamada, K., Ota, K., Matsubara, C., Inutsuka, A., Sato, M., Ohkura, M., Yamanaka, A., Yanagawa, Y., Nakai, J., Hayashi, Y., Larkum, M.E., & Murayama, M. (2015).
  A Top-Down Cortical Circuit for Accurate Sensory Perception. Neuron, 86(5), 1304-16. [PubMed:26004915] [WorldCat] [DOI] [Google Scholar]

2014

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  Bosch, M., Castro, J., Saneyoshi, T., Matsuno, H., Sur, M., & Hayashi, Y. (2014).
  Structural and molecular remodeling of dendritic spine substructures during long-term potentiation. Neuron, 82(2), 444-59. [PubMed:24742465] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Martinez-Lozada, Z., Waggener, C.T., Kim, K., Zou, S., Knapp, P.E., Hayashi, Y., Ortega, A., & Fuss, B. (2014).
  Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain. Glia, 62(9), 1543-1558. [PubMed:24866099] [PMC] [WorldCat] [DOI] [Google Scholar]

2013

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  Ueda, Y., & Hayashi, Y. (2013).
  PIP₃ regulates spinule formation in dendritic spines during structural long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(27), 11040-7. [PubMed:23825409] [PMC] [WorldCat] [DOI]

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2012

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  Wang, D.O., Matsuno, H., Ikeda, S., Nakamura, A., Yanagisawa, H., Hayashi, Y., & Okamoto, A. (2012).
  A quick and simple FISH protocol with hybridization-sensitive fluorescent linear oligodeoxynucleotide probes. RNA (New York, N.Y.), 18(1), 166-75. [PubMed:22101241] [PMC] [WorldCat] [DOI] [Google Scholar]

2011

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  Mower, A.F., Kwok, S., Yu, H., Majewska, A.K., Okamoto, K., Hayashi, Y., & Sur, M. (2011).
  Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo. Proceedings of the National Academy of Sciences of the United States of America, 108(52), 21241-6. [PubMed:22160721] [PMC] [WorldCat] [DOI] [Google Scholar]

2009

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  Hayashi, M.K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M.H., Xu, R.M., Li, H., Sala, C., & Hayashi, Y. (2009).
  The postsynaptic density proteins Homer and Shank form a polymeric network structure. Cell, 137(1), 159-71. [PubMed:19345194] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Kishi, K., van Vugt, M.A., Okamoto, K., Hayashi, Y., & Yaffe, M.B. (2009).
  Functional dynamics of Polo-like kinase 1 at the centrosome. Molecular and cellular biology, 29(11), 3134-50. [PubMed:19307309] [PMC] [WorldCat] [DOI] [Google Scholar]

2008

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  Niemann, S., Landers, J.E., Churchill, M.J., Hosler, B., Sapp, P., Speed, W.C., Lahn, B.T., Kidd, K.K., Brown, R.H., & Hayashi, Y. (2008).
  Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele. Neurology, 70(9), 666-76. [PubMed:17687115] [WorldCat] [DOI]

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  Kwok, S., Lee, C., Sánchez, S.A., Hazlett, T.L., Gratton, E., & Hayashi, Y. (2008).
  Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity. Biochemical and biophysical research communications, 369(2), 519-25. [PubMed:18302935] [PMC] [WorldCat] [DOI] [Google Scholar]

2007

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  Futai, K., Kim, M.J., Hashikawa, T., Scheiffele, P., Sheng, M., & Hayashi, Y. (2007).
  Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nature neuroscience, 10(2), 186-95. [PubMed:17237775] [PMC] [WorldCat] [DOI]

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  Okamoto, K., Narayanan, R., Lee, S.H., Murata, K., & Hayashi, Y. (2007).
  The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure. Proceedings of the National Academy of Sciences of the United States of America, 104(15), 6418-23. [PubMed:17404223] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Niemann, S., Kanki, H., Fukui, Y., Takao, K., Fukaya, M., Hynynen, M.N., Churchill, M.J., Shefner, J.M., Bronson, R.T., Brown, R.H., Watanabe, M., Miyakawa, T., Itohara, S., & Hayashi, Y. (2007).
  Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes. The European journal of neuroscience, 26(6), 1407-20. [PubMed:17880385] [WorldCat] [DOI] [Google Scholar]

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  Kim, M.J., Futai, K., Jo, J., Hayashi, Y., Cho, K., & Sheng, M. (2007).
  Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95. Neuron, 56(3), 488-502. [PubMed:17988632] [WorldCat] [DOI] [Google Scholar]

2006

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  Okamoto, K., & Hayashi, Y. (2006).
  Visualization of F-actin and G-actin equilibrium using fluorescence resonance energy transfer (FRET) in cultured cells and neurons in slices. Nature protocols, 1(2), 911-9. [PubMed:17406324] [WorldCat] [DOI] [Google Scholar]

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  Hayashi, M.K., Ames, H.M., & Hayashi, Y. (2006).
  Tetrameric hub structure of postsynaptic scaffolding protein homer. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(33), 8492-501. [PubMed:16914674] [PMC] [WorldCat] [DOI] [Google Scholar]

2005

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  Takao, K., Okamoto, K., Nakagawa, T., Neve, R.L., Nagai, T., Miyawaki, A., Hashikawa, T., Kobayashi, S., & Hayashi, Y. (2005).
  Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(12), 3107-12. [PubMed:15788767] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Howarth, M., Takao, K., Hayashi, Y., & Ting, A.Y. (2005).
  Targeting quantum dots to surface proteins in living cells with biotin ligase. Proceedings of the National Academy of Sciences of the United States of America, 102(21), 7583-8. [PubMed:15897449] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Fukaya, M., Hayashi, Y., & Watanabe, M. (2005).
  NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneurons. The European journal of neuroscience, 21(5), 1432-6. [PubMed:15813953] [WorldCat] [DOI] [Google Scholar]

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  Nolan, E.M., Jaworski, J., Okamoto, K., Hayashi, Y., Sheng, M., & Lippard, S.J. (2005).
  QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II). Journal of the American Chemical Society, 127(48), 16812-23. [PubMed:16316228] [PMC] [WorldCat] [DOI] [Google Scholar]

2004

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  Okamoto, K., Nagai, T., Miyawaki, A., & Hayashi, Y. (2004).
  Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity. Nature neuroscience, 7(10), 1104-12. [PubMed:15361876] [WorldCat] [DOI] [Google Scholar]

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  Nakagawa, T., Futai, K., Lashuel, H.A., Lo, I., Okamoto, K., Walz, T., Hayashi, Y., & Sheng, M. (2004).
  Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron, 44(3), 453-67. [PubMed:15504326] [WorldCat] [DOI] [Google Scholar]

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  Li, Z., Okamoto, K., Hayashi, Y., & Sheng, M. (2004).
  The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell, 119(6), 873-87. [PubMed:15607982] [WorldCat] [DOI] [Google Scholar]

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  Chang, C.J., Nolan, E.M., Jaworski, J., Okamoto, K., Hayashi, Y., Sheng, M., & Lippard, S.J. (2004).
  ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopy. Inorganic chemistry, 43(21), 6774-9. [PubMed:15476377] [WorldCat] [DOI] [Google Scholar]

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  Semino, C.E., Kasahara, J., Hayashi, Y., & Zhang, S. (2004).
  Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold. Tissue engineering, 10(3-4), 643-55. [PubMed:15165480] [WorldCat] [DOI] [Google Scholar]

2003

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  Sala, C., Futai, K., Yamamoto, K., Worley, P.F., Hayashi, Y., & Sheng, M. (2003).
  Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(15), 6327-37. [PubMed:12867517] [PMC] [WorldCat] [DOI] [Google Scholar]

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  Kawamura M, Namba H, Otsu. Y, Hayashi Y, Takei N, Nawa H
  Characterization of novel bicistronic sindbis virus vectors, SinEGdsp and SinIRES-EG, in cultured neurons.
  Recent Res. Devel. Neurochem.: 2003 6():105-120.

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  Jourdi, H., Iwakura, Y., Narisawa-Saito, M., Ibaraki, K., Xiong, H., Watanabe, M., Hayashi, Y., Takei, N., & Nawa, H. (2003).
  Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. Developmental biology, 263(2), 216-30. [PubMed:14597197] [PMC] [WorldCat] [DOI] [Google Scholar]

2001

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  Shi, S., Hayashi, Y., Esteban, J.A., & Malinow, R. (2001).
  Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell, 105(3), 331-43. [PubMed:11348590] [WorldCat] [DOI] [Google Scholar]

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  Nishi, M., Hinds, H., Lu, H.P., Kawata, M., & Hayashi, Y. (2001).
  Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner. The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(23), RC185. [PubMed:11717388] [PMC] [WorldCat] [DOI] [Google Scholar]

2000

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  Zhu, J.J., Esteban, J.A., Hayashi, Y., & Malinow, R. (2000).
  Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity. Nature neuroscience, 3(11), 1098-106. [PubMed:11036266] [WorldCat] [DOI] [Google Scholar]

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  Hayashi, Y., Shi, S.H., Esteban, J.A., Piccini, A., Poncer, J.C., & Malinow, R. (2000).
  Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science (New York, N.Y.), 287(5461), 2262-7. [PubMed:10731148] [WorldCat] [DOI] [Google Scholar]

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  Carlezon, W.A., Haile, C.N., Coppersmith, R., Hayashi, Y., Malinow, R., Neve, R.L., & Nestler, E.J. (2000).
  Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(5), RC62. [PubMed:10684909] [PMC] [WorldCat] [DOI] [Google Scholar]

1999

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  Shi, S.H., Hayashi, Y., Petralia, R.S., Zaman, S.H., Wenthold, R.J., Svoboda, K., & Malinow, R. (1999).
  Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science (New York, N.Y.), 284(5421), 1811-6. [PubMed:10364548] [WorldCat] [DOI] [Google Scholar]

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  Mainen, Z.F., Maletic-Savatic, M., Shi, S.H., Hayashi, Y., Malinow, R., & Svoboda, K. (1999).
  Two-photon imaging in living brain slices. Methods (San Diego, Calif.), 18(2), 231-9, 181. [PubMed:10356355] [WorldCat] [DOI] [Google Scholar]

1997

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  Hayashi, Y., Ishida, A., Katagiri, H., Mishina, M., Fujisawa, H., Manabe, T., & Takahashi, T. (1997).
  Calcium- and calmodulin-dependent phosphorylation of AMPA type glutamate receptor subunits by endogenous protein kinases in the post-synaptic density. Brain research. Molecular brain research, 46(1-2), 338-42. [PubMed:9191113] [WorldCat] [DOI] [Google Scholar]

1996

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  Sekiyama, N., Hayashi, Y., Nakanishi, S., Jane, D.E., Tse, H.W., Birse, E.F., & Watkins, J.C. (1996).
  Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. British journal of pharmacology, 117(7), 1493-503. [PubMed:8730745] [PMC] [WorldCat] [DOI] [Google Scholar]

1994

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  Okamoto, N., Hori, S., Akazawa, C., Hayashi, Y., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1994).
  Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. The Journal of biological chemistry, 269(2), 1231-6. [PubMed:8288585] [WorldCat] [Google Scholar]

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  Kaba, H., Hayashi, Y., Higuchi, T., & Nakanishi, S. (1994).
  Induction of an olfactory memory by the activation of a metabotropic glutamate receptor. Science (New York, N.Y.), 265(5169), 262-4. [PubMed:8023145] [WorldCat] [DOI] [Google Scholar]



• Hayashi, Y., Sekiyama, N., Nakanishi, S., Jane, D.E., Sunter, D.C., Birse, E.F., Udvarhelyi, P.M., & Watkins, J.C. (1994).
  Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(5 Pt 2), 3370-7. [PubMed:8182479] [PMC] [WorldCat] [DOI] [Google Scholar]

1993

• 

  Sugimoto, Y., Negishi, M., Hayashi, Y., Namba, T., Honda, A., Watabe, A., Hirata, M., Narumiya, S., & Ichikawa, A. (1993).
  Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins. The Journal of biological chemistry, 268(4), 2712-8. [PubMed:8381413] [WorldCat] [Google Scholar]

• 

  Negishi, M., Sugimoto, Y., Hayashi, Y., Namba, T., Honda, A., Watabe, A., Narumiya, S., & Ichikawa, A. (1993).
  Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding. Biochimica et biophysica acta, 1175(3), 343-50. [PubMed:8382086] [WorldCat] [DOI] [Google Scholar]

• 

  Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa-Meguro, R., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1993).
  Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature, 366(6456), 687-90. [PubMed:7903116] [WorldCat] [DOI] [Google Scholar]

1992

• 

  Sugimoto, Y., Namba, T., Honda, A., Hayashi, Y., Negishi, M., Ichikawa, A., & Narumiya, S. (1992).
  Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype. The Journal of biological chemistry, 267(10), 6463-6. [PubMed:1372606] [WorldCat] [Google Scholar]

• 

  Namba, T., Sugimoto, Y., Hirata, M., Hayashi, Y., Honda, A., Watabe, A., Negishi, M., Ichikawa, A., & Narumiya, S. (1992).
  Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochemical and biophysical research communications, 184(3), 1197-203. [PubMed:1375456] [WorldCat] [DOI] [Google Scholar]

• 

  Hayashi, Y., Tanabe, Y., Aramori, I., Masu, M., Shimamoto, K., Ohfune, Y., & Nakanishi, S. (1992).
  Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. British journal of pharmacology, 107(2), 539-43. [PubMed:1330184] [PMC] [WorldCat] [DOI] [Google Scholar]

1991

• 

  Hirata, M., Hayashi, Y., Ushikubi, F., Yokota, Y., Kageyama, R., Nakanishi, S., & Narumiya, S. (1991).
  Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature, 349(6310), 617-20. [PubMed:1825698] [WorldCat] [DOI] [Google Scholar]

1990

• 

  Koshimura, K., Miwa, S., Lee, K., Hayashi, Y., Hasegawa, H., Hamahata, K., Fujiwara, M., Kimura, M., & Itokawa, Y. (1990).
  Effects of choline administration on in vivo release and biosynthesis of acetylcholine in the rat striatum as studied by in vivo brain microdialysis. Journal of neurochemistry, 54(2), 533-9. [PubMed:2299351] [WorldCat] [DOI] [Google Scholar]

• 

  Hayashi, Y., Miwa, S., Lee, K., Koshimura, K., Hamahata, K., Hasegawa, H., Fujiwara, M., & Watanabe, Y. (1990).
  Enhancement of in vivo tyrosine hydroxylation in the rat adrenal gland under hypoxic conditions. Journal of neurochemistry, 54(4), 1115-21. [PubMed:1968954] [WorldCat] [DOI] [Google Scholar]

1989

• 

  Lee, K., Miwa, S., Hayashi, Y., Koshimura, K., Fujiwara, M., & Orii, Y. (1989).
  Effects of hypoxia on noradrenaline release and neuronal reuptake in isolated rabbit thoracic aortic strips. Naunyn-Schmiedeberg's archives of pharmacology, 339(5), 503-8. [PubMed:2770884] [WorldCat] [DOI] [Google Scholar]

1988

• 

  Hayashi, Y., Miwa, S., Lee, K., Koshimura, K., Kamel, A., Hamahata, K., & Fujiwara, M. (1988).
  A nonisotopic method for determination of the in vivo activities of tyrosine hydroxylase in the rat adrenal gland. Analytical biochemistry, 168(1), 176-83. [PubMed:2896473] [WorldCat] [DOI] [Google Scholar]

• 

  Lee, K., Miwa, S., Hayashi, Y., Koshimura, K., Taniguchi, T., Orii, Y., & Fujiwara, M. (1988).
  Effects of hypoxia on contractile responses of rabbit aortic strips to transmural electrical stimulation. Naunyn-Schmiedeberg's archives of pharmacology, 338(3), 275-81. [PubMed:3194036] [WorldCat] [DOI] [Google Scholar]

Reviews and Commentaries

2017

• 

  Lissek, T., Adams, M., Adelman, J., Ahissar, E., Akaaboune, M., Akil, H., al'Absi, M., Arain, F., Arango-Lasprilla, J.C., Atasoy, D., Avila, J., Badawi, A., Bading, H., Baig, A.M., Baleriola, J., Belmonte, C., Bertocchi, I., Betz, H., Blakemore, C., Blanke, O., Boehm-Sturm, P., Bonhoeffer, T., Bonifazi, P., Brose, N., Campolongo, P., Celikel, T., Chang, C.C., Chang, T.Y., Citri, A., ..., & Hasan, M.T. (2017).
  Building Bridges through Science. Neuron, 96(4), 730-735. [PubMed:29144972] [WorldCat] [DOI] [Google Scholar]

2016

• 

  Kim, K., Saneyoshi, T., Hosokawa, T., Okamoto, K., & Hayashi, Y. (2016).
  Interplay of enzymatic and structural functions of CaMKII in long-term potentiation. Journal of neurochemistry, 139(6), 959-972. [PubMed:27207106] [WorldCat] [DOI] [Google Scholar]

2014

• 

  Saneyoshi, T., & Hayashi, Y. (2014).
  Synapse reorganization-a new partnership revealed. The EMBO journal, 33(12), 1292-4. [PubMed:24764316] [PMC] [WorldCat] [DOI] [Google Scholar]

• 

  Kim, K., & Hayashi, Y. (2014).
  CaMKII: the Swiss army knife of synaptic plasticity. The Journal of physiology, 592(22), 4807-8. [PubMed:25399030] [PMC] [WorldCat] [DOI] [Google Scholar]

2013

• 

  Ueda, Y., Kwok, S., & Hayashi, Y. (2013).
  Application of FRET probes in the analysis of neuronal plasticity. Frontiers in neural circuits, 7, 163. [PubMed:24133415] [PMC] [WorldCat] [DOI] [Google Scholar]

2012

• 

  Saneyoshi, T., & Hayashi, Y. (2012).
  The Ca2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines. Cytoskeleton (Hoboken, N.J.), 69(8), 545-54. [PubMed:22566410] [WorldCat] [DOI] [Google Scholar]

• 

  Sakaguchi, M., & Hayashi, Y. (2012).
  Catching the engram: strategies to examine the memory trace. Molecular brain, 5, 32. [PubMed:22999350] [PMC] [WorldCat] [DOI] [Google Scholar]

• 

  Hayashi, Y., Okamoto, K., Bosch, M., & Futai, K. (2012).
  Roles of neuronal activity-induced gene products in Hebbian and homeostatic synaptic plasticity, tagging, and capture. Advances in experimental medicine and biology, 970, 335-54. [PubMed:22351063] [WorldCat] [DOI] [Google Scholar]

• 

  Bosch, M., & Hayashi, Y. (2012).
  Structural plasticity of dendritic spines. Current opinion in neurobiology, 22(3), 383-8. [PubMed:21963169] [PMC] [WorldCat] [DOI] [Google Scholar]

2010

• 

  Malinow, R., Hayashi, Y., Maletic-Savatic, M., Zaman, S.H., Poncer, J.C., Shi, S.H., Esteban, J.A., Osten, P., & Seidenman, K. (2010).
  Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection. Cold Spring Harbor protocols, 2010(4), pdb.prot5406. [PubMed:20360360] [PMC] [WorldCat] [DOI] [Google Scholar]

2009

• 

  Okamoto, K., Bosch, M., & Hayashi, Y. (2009).
  The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag? Physiology (Bethesda, Md.), 24, 357-66. [PubMed:19996366] [WorldCat] [DOI] [Google Scholar]

• 

  Hayashi, Y. (2009).
  Long-term potentiation: two pathways meet at neurogranin. The EMBO journal, 28(19), 2859-60. [PubMed:19809472] [PMC] [WorldCat] [DOI] [Google Scholar]

2008

• 

  Poo, M.M., Sander, L., Fivaz, M., & Hayashi, Y. (2008).
  Asian promise: the state and future of collaborations in neuroscience. Nature reviews. Neuroscience, 9(11), 881-4. [PubMed:18843270] [WorldCat] [DOI] [Google Scholar]

2005

• 

  Hayashi, Y., & Majewska, A.K. (2005).
  Dendritic spine geometry: functional implication and regulation. Neuron, 46(4), 529-32. [PubMed:15944122] [WorldCat] [DOI]

2003

• File:Futai Excitatory-Inhibitory Balance: Synapse, Circuits, Systems.pdf

  K Futai, Y Hayashi
  Dynamism of postsynaptic proteins as the mechanism of synaptic plasticity
  In Excitatory-Inhibitory Balance, Synapses, Circuits, Systems pp. 45-58, edited by Hensch and Fagiolini. Springer, 2003
  [Google Scholar]

2000

• 

  Malinow, R., Mainen, Z.F., & Hayashi, Y. (2000).
  LTP mechanisms: from silence to four-lane traffic. Current opinion in neurobiology, 10(3), 352-7. [PubMed:10851179] [WorldCat] [DOI]

• 

  Malinow, R., Hayashi, Y., Maletic-Savatic, M., Zaman, S.H., Poncer, J.C., Shi, S.H., Esteban, J.A., Osten, P., & Seidenman, K. (2010).
  Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection. Cold Spring Harbor protocols, 2010(4), pdb.prot5406. [PubMed:20360360] [PMC] [WorldCat] [DOI]

1996

• 

  Nakanishi, S., Nakajima, Y., Nomura, A., Masu, M., Iwakabe, H., Hayashi, Y., & Yokoi, M. (1996).
  Functions and roles of glutamate receptors in synaptic transmission and plasticity. Cold Spring Harbor symposia on quantitative biology, 61, 67-75. [PubMed:9246436] [WorldCat] [Google Scholar]

1994

• 

  Nakanishi, S., Masu, M., Bessho, Y., Nakajima, Y., Hayashi, Y., & Shigemoto, R. (1994).
  Molecular diversity of glutamate receptors and their physiological functions. EXS, 71, 71-80. [PubMed:8032174] [WorldCat] [DOI] [Google Scholar]

1993

• Narumiya, S., Hirata, N., Namba, T., Hayashi, Y., Ushikubi, F., Sugimoto, Y., Negishi, M., & Ichikawa, A. (1993).
  Structure and function of prostanoid receptors. Journal of lipid mediators, 6(1-3), 155-61. [PubMed:8395239] [WorldCat]

  

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Reviews, Book Chapter, Commentary