Answering the mistery of memory - Revision history

Yasunorihayashi at 13:08, 13 April 2026

2026-04-13T13:08:22Z

← Older revision		Revision as of 13:08, 13 April 2026
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	[[j:記憶の謎を解き明かす]]		[[j:記憶の謎を解き明かす]]
			[[file:Cajal Hippocampus.jpg\|thumbnail\|Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).]]
			[[file:Thy1-hippocampus-merge.png\|thumbnail\|Mouse hippocampal section from a transgenic line expressing G-CaMP7 and DsRed2.]]
	In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.		In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.

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	* [[Projects#Molecular_Mechanisms_of_Structural_Plasticity_of_Dendritic_Spines\|Molecular Mechanisms of Structural Plasticity of Dendritic Spines]]		* [[Projects#Molecular_Mechanisms_of_Structural_Plasticity_of_Dendritic_Spines\|Molecular Mechanisms of Structural Plasticity of Dendritic Spines]]
	* [[Projects#Dynamic_Behavior_of_Cellular_Memory_Engram\|Dynamic Behavior of Cellular Memory Engram]]		* [[Projects#Dynamic_Behavior_of_Cellular_Memory_Engram\|Dynamic Behavior of Cellular Memory Engram]]

	~~Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).~~

	~~Mouse hippocampal section from a transgenic line expressing G-CaMP7 and DsRed2.~~

	== Latest News ==		== Latest News ==

Yasunorihayashi at 12:33, 13 April 2026

2026-04-13T12:33:16Z

← Older revision		Revision as of 12:33, 13 April 2026
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	Our laboratory addresses this problem through an integrative, multi-scale approach spanning molecular, cellular, circuit, and behavioral levels:		Our laboratory addresses this problem through an integrative, multi-scale approach spanning molecular, cellular, circuit, and behavioral levels:

	Protein trafficking in long-term potentiation		* [[Projects#Protein_Trafficking_and_Long-term_Potentiation\|Protein trafficking in long-term potentiation]]
	~~Liquid–liquid~~ phase separation in synaptic plasticity		* [[Projects#Liquid-liquid_phase_separation_and_synaptic_plasticity\|Liquid-liquid phase separation and synaptic plasticity]]
	Molecular ~~mechanisms underlying structural plasticity~~ of ~~dendritic spines~~		* [[Projects#Molecular_Mechanisms_of_Structural_Plasticity_of_Dendritic_Spines\|Molecular Mechanisms of Structural Plasticity of Dendritic Spines]]
	Dynamic ~~properties~~ of ~~cellular memory engrams~~		* [[Projects#Dynamic_Behavior_of_Cellular_Memory_Engram\|Dynamic Behavior of Cellular Memory Engram]]

	Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).		Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).
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	== Latest News ==		== Latest News ==

	November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”<br>		* November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”<br>
	April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”		* April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”

Yasunorihayashi at 12:26, 13 April 2026

2026-04-13T12:26:56Z

← Older revision		Revision as of 12:26, 13 April 2026
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	~~{{Language\|en=Answering the mistery of memory\|ja=~~記憶の謎を解き明かす}}		[[j:記憶の謎を解き明かす]]
	In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.		In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.

Yasunorihayashi at 04:29, 13 April 2026

2026-04-13T04:29:11Z

← Older revision		Revision as of 04:29, 13 April 2026
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			{{Language\|en=Answering the mistery of memory\|ja=記憶の謎を解き明かす}}
	In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.		In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.

Yasunorihayashi at 14:01, 11 April 2026

2026-04-11T14:01:24Z

← Older revision		Revision as of 14:01, 11 April 2026
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	== Latest News ==		== Latest News ==

	November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”		November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”<br>
	April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”		April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”

Yasunorihayashi at 09:50, 11 April 2026

2026-04-11T09:50:36Z

← Older revision		Revision as of 09:50, 11 April 2026
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	~~Here is~~ a ~~more polished and coherent version~~, ~~with~~ a ~~slightly more continuous narrative tone~~ and ~~tightened phrasing:~~		In 1953, a young man who would later become known as patient H.M. underwent an experimental surgical procedure involving bilateral resection of the hippocampi as a treatment for intractable epilepsy. While the operation successfully alleviated his seizures, it resulted in a profound and unanticipated cognitive deficit. Although previously established memories remained largely intact, he was unable to form new declarative memories.

	---		Subsequent studies of H.M. demonstrated that the hippocampus is indispensable for the initial encoding of memory, yet is not the ultimate site of long-term storage. However, the mechanisms by which memories are encoded within the hippocampus, reorganized across distributed brain networks, and subsequently retrieved remain incompletely understood. Elucidating these processes constitutes a central objective in contemporary neuroscience.

	~~In 1953~~, a young man who would later become known as patient H.M. underwent an experimental surgery in which his hippocampi were bilaterally removed to treat intractable epilepsy. Although the procedure successfully controlled his seizures, ~~it resulted in a profound~~ and ~~unexpected deficit. While he retained previously formed memories, he was no longer able to form new ones.~~		Our laboratory addresses this problem through an integrative, multi-scale approach spanning molecular, cellular, circuit, and behavioral levels:

	Studies of H.M.’s condition established that the hippocampus is essential for the initial formation of memory, but not for its long-term storage. Yet the fundamental question remains unresolved: how are memories encoded within the hippocampus, transferred to distributed cortical networks, and later retrieved? Addressing this problem continues to be one of the central challenges in neuroscience.		Protein trafficking in long-term potentiation
			Liquid–liquid phase separation in synaptic plasticity
	~~In our laboratory, we investigate these questions across multiple levels, from molecular mechanisms to animal behavior:~~		Molecular mechanisms underlying structural plasticity of dendritic spines
			Dynamic properties of cellular memory engrams
	* Protein trafficking ~~and~~ long-term potentiation
	* Liquid–liquid phase separation in synaptic plasticity
	* Molecular mechanisms of structural plasticity in dendritic spines
	* Dynamic properties of cellular memory engrams

	Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).		Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).
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	== Latest News ==		== Latest News ==

	* November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”		November 12, 2021: Work by Akihiro Goto published in Science. See “Erasing memory with light – understanding why sleep is necessary for memory.”
	* April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”		April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in Nature Neuroscience. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”

	~~---~~

	~~If you would like, I can tune the tone further—for example, making it more formal for a grant homepage, or more accessible for a general audience.~~

Yasunorihayashi: Created page with "Here is a more polished and coherent version, with a slightly more continuous narrative tone and tightened phrasing: --- In 1953, a young man who would later become known as patient H.M. underwent an experimental surgery in which his hippocampi were bilaterally removed to treat intractable epilepsy. Although the procedure successfully controlled his seizures, it resulted in a profound and unexpected deficit. While he retained previously formed memories, he was no longe..."

2026-04-11T09:44:50Z

Created page with "Here is a more polished and coherent version, with a slightly more continuous narrative tone and tightened phrasing: --- In 1953, a young man who would later become known as patient H.M. underwent an experimental surgery in which his hippocampi were bilaterally removed to treat intractable epilepsy. Although the procedure successfully controlled his seizures, it resulted in a profound and unexpected deficit. While he retained previously formed memories, he was no longe..."

New page

Here is a more polished and coherent version, with a slightly more continuous narrative tone and tightened phrasing:

---

In 1953, a young man who would later become known as patient H.M. underwent an experimental surgery in which his hippocampi were bilaterally removed to treat intractable epilepsy. Although the procedure successfully controlled his seizures, it resulted in a profound and unexpected deficit. While he retained previously formed memories, he was no longer able to form new ones.

Studies of H.M.’s condition established that the hippocampus is essential for the initial formation of memory, but not for its long-term storage. Yet the fundamental question remains unresolved: how are memories encoded within the hippocampus, transferred to distributed cortical networks, and later retrieved? Addressing this problem continues to be one of the central challenges in neuroscience.

In our laboratory, we investigate these questions across multiple levels, from molecular mechanisms to animal behavior:

* Protein trafficking and long-term potentiation
* Liquid–liquid phase separation in synaptic plasticity
* Molecular mechanisms of structural plasticity in dendritic spines
* Dynamic properties of cellular memory engrams

Original drawing of the hippocampus by Santiago Ramón y Cajal (Golgi staining).

Mouse hippocampal section from a transgenic line expressing G-CaMP7 and DsRed2.

== Latest News ==

* November 12, 2021: Work by Akihiro Goto published in *Science*. See “Erasing memory with light – understanding why sleep is necessary for memory.”
* April 29, 2021: Work by Tomohisa Hosokawa and Pinwu Liu published in *Nature Neuroscience*. See “An oil–water relationship explains memory formation – a new protein segregation mechanism in the brain.”

---

If you would like, I can tune the tone further—for example, making it more formal for a grant homepage, or more accessible for a general audience.